GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7647973 | 1 | rs1464569 | chr3:49460350 | AMT | chr3:49454212-49460012:- | 0.14 | 4.69 | 3.13E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1464569 | chr3:49460350 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.66 | 0.000268 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1464569 | chr3:49460350 | GMPPB | chr3:49758932-49761384:- | -0.12 | -3.7 | 0.000225 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1464569 | chr3:49460350 | NCKIPSD | chr3:48711280-48723334:- | 0.16 | 3.99 | 6.95E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1464569 | chr3:49460350 | P4HTM | chr3:49027341-49044579:+ | 0.09 | 3.64 | 0.000285 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1464569 | chr3:49460350 | TREX1 | chr3:48501186-48509043:+ | -0.12 | -3.85 | 0.000124 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1464569 | chr3:49460350 | WDR6 | chr3:49044637-49053386:+ | -0.17 | -5 | 6.58E-7 | Menarche (age at onset) |
| BRCA | cis | rs13424612 | 1 | rs1465880 | chr2:240932326 | NDUFA10 | chr2:240900158-240964798:- | 0.26 | 6.72 | 2.91E-11 | Odorant perception (isobutyraldehyde) |
| BRCA | cis | rs3796619 | 1 | rs1466215 | chr4:1072220 | CRIPAK | chr4:1385340-1389782:+ | 0.11 | 3.4 | 0.000708 | Recombination rate (males) |
| BRCA | cis | rs3796619 | 1 | rs1466215 | chr4:1072220 | KIAA1530 | chr4:1341104-1381836:+ | 0.11 | 3.64 | 0.000289 | Recombination rate (males) |
| BRCA | cis | rs1466788 | 1 | rs1466788 | chr1:110618730 | ALX3 | chr1:110602998-110613322:- | -0.13 | -3.89 | 0.000108 | Blood metabolite levels |
| BRCA | cis | rs11696845 | 1 | rs1467472 | chr20:43371551 | KCNK15 | chr20:43374488-43379666:+ | 0.13 | 4.54 | 6.16E-6 | Obesity-related traits |
| BRCA | cis | rs2905426 | 1 | rs1469712 | chr19:19528821 | CILP2 | chr19:19649074-19657466:+ | 0.1 | 3.78 | 0.000166 | Schizophrenia |
| BRCA | cis | rs2905426 | 1 | rs1469712 | chr19:19528821 | HAPLN4 | chr19:19366453-19384074:- | 0.21 | 6.86 | 1.19E-11 | Schizophrenia |
| BRCA | cis | rs6532023 | 1 | rs1471399 | chr4:88774073 | SPP1 | chr4:88896802-88904562:+ | -0.18 | -5.8 | 8.64E-9 | Bone mineral density;Bone mineral density (paediatric, total body less head) |